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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
18.79
Human Site:
S1212
Identified Species:
29.52
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S1212
E
D
V
L
A
G
M
S
G
K
A
I
K
G
K
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1220
E
D
V
L
A
G
M
S
G
K
A
I
K
G
K
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1206
E
D
I
L
A
G
M
S
G
K
A
I
K
G
K
Dog
Lupus familis
XP_534241
2041
231068
A1630
E
D
I
L
A
G
M
A
G
K
A
I
K
G
K
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S1200
E
D
I
L
A
G
M
S
G
K
A
I
K
G
K
Rat
Rattus norvegicus
P41516
1526
173202
L1141
T
K
E
K
K
D
E
L
C
K
Q
R
D
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
S1515
E
D
I
L
A
G
M
S
G
K
A
I
K
G
K
Chicken
Gallus gallus
O42131
1627
183228
V1217
E
D
V
L
A
G
M
V
G
K
P
I
K
G
K
Frog
Xenopus laevis
NP_001082502
1579
178601
A1184
E
E
E
S
Q
S
L
A
G
K
V
V
K
G
K
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
A1211
E
S
V
N
L
G
K
A
V
K
L
V
K
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
R1062
M
C
D
E
L
L
K
R
G
Y
R
P
D
P
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
L1135
E
E
Q
K
L
K
E
L
R
E
S
G
E
I
E
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
Y1063
L
Y
H
K
R
K
A
Y
L
E
G
I
L
E
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
G1088
S
V
E
A
A
I
A
G
A
V
D
D
D
A
A
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
K1043
K
E
L
T
V
T
N
K
P
R
N
A
I
I
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
93.3
86.6
N.A.
93.3
13.3
N.A.
93.3
86.6
40
46.6
N.A.
6.6
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
100
86.6
66.6
60
N.A.
6.6
N.A.
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
54
0
14
20
7
0
40
7
0
7
14
% A
% Cys:
0
7
0
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
0
47
7
0
0
7
0
0
0
0
7
7
20
0
0
% D
% Glu:
67
20
20
7
0
0
14
0
0
14
0
0
7
14
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
54
0
7
60
0
7
7
0
60
0
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
27
0
0
7
0
0
0
0
0
54
7
14
0
% I
% Lys:
7
7
0
20
7
14
14
7
0
67
0
0
60
0
67
% K
% Leu:
7
0
7
47
20
7
7
14
7
0
7
0
7
0
0
% L
% Met:
7
0
0
0
0
0
47
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
0
7
0
0
0
7
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
7
0
7
7
0
7
0
% P
% Gln:
0
0
7
0
7
0
0
0
0
0
7
0
0
0
7
% Q
% Arg:
0
0
0
0
7
0
0
7
7
7
7
7
0
0
0
% R
% Ser:
7
7
0
7
0
7
0
34
0
0
7
0
0
0
0
% S
% Thr:
7
0
0
7
0
7
0
0
0
0
0
0
0
0
0
% T
% Val:
0
7
27
0
7
0
0
7
7
7
7
14
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
7
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _